Hb H. Hemoglobin H (Hb H) disease is the most common form of thalassemia intermedia and has many features that require careful consideration in management In the majority of cases Hb H disease results from double heterozygosity for alpha(0)thalassemia due to deletions that remove both linked alphaglobin genes on chromosome 16 and deletional alpha(+)thalassemia from single alphaglobin gene Author Suthat Fucharoen Vip ViprakasitCited by Publish Year 2009.
Hemoglobin H (Hb H) disease is the most severe nonfatal form of αthalassemia syndrome mostly caused by molecular defects of the αglobin genes in which αglobin expression is decreased This condition has long been thought to be a rather mild clinical condition since the majority of patients with Hb H have compensated hemolytic anemia Author Suthat Fucharoen Vip ViprakasitCited by Publish Year 2009.
Hb H disease: clinical course and disease modifiers
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Hb H disease: clinical course and disease modifiers
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Hemoglobin electrophoresis is not usually helpful for diagnosis of αthalassemia except in infants in whom the presence of Hb Bart’s or Hb H indicates αthalassemia but hemoglobin electrophoresis is usually normal in individuals with αthalassemia trait However in an individual with Hb H disease the presence of hemoglobin H in electrophoresis along with Hb Bart’s is a useful.